Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

Ding Yan Yuhang, a Shandong player who hasn’t updated his personal social dynamics for a long time, recently updated his personal social media. He took a big photo of the China men’s basketball team participating in this World Cup qualifier, and gave his best wishes to his friends. Originally, this was a perfectly normal dynamic, but some fans thought that Ding Yanyuhang was rubbing against the popularity of China men’s basketball team. In fact, it was a bit unfair to Ding Yanyuhang. After all, Xiaoding’s wishes for the national team and friends were sincere, and fans should not be mixed with too much personal feelings.

For Ding Yan Yuhang, some fans also very much hope that he can return to the national team. It is also a great encouragement for Ding Yan Yuhang to see that Abdul Salamu, who has suffered serious injuries like him, has already returned to the national team. Du Feng has also given all players a chance. After all, it is the greatest honor for a player to play for the national team, and it is also a very confidence-boosting thing to have the opportunity to enter the national team after a serious injury.

Recently, there are a lot of news about China men’s basketball team, one of which makes the fans very worried. That is, when qi zhou participated in nbl preseason, many of their opponents were found to have COVID-19. qi zhou, as a close contact, is likely to be isolated and missed. However, recently, some media broke the news that qi zhou appeared in China men’s basketball team’s training abroad, which broke the previous rumor that qi zhou would miss the preliminaries. China men’s basketball team has been sent to the strongest team in the world, hoping that they can break into the final with all their might.

The second phase of the cba is about to start, and wcba has already gone through six rounds. Compared with the attention of CBA in China, there are few fans in wcba. Up to now, three teams in WCBA have maintained an unbeaten record this season, namely the defending champion Inner Mongolia team, Sichuan team and Shandong team. In the first six rounds, Inner Mongolia team beat their opponents by a big score, and their biggest competitor this season is Sichuan team, which is temporarily ranked third.

In fact, after seeing the lineups of the two teams, the fans were not surprised why the two teams competed for the championship. Together, the two teams gathered a total of 17 national players. The Inner Mongolia team gathered 9 national players including Li Yueru, Yang Liwei, Huang Sijing, Zhao Shuang, Zhang Ru, Pan Zhenqi, Ma Xueya, Wei Wei and Li Yifan, while the Sichuan team had Han Xu, Wu Di, Shao Ting, Li Meng, Sun Mengran, Li Shanshan and so on.

In today’s cba league, Guangdong men’s basketball team and Liaoning men’s basketball team are still the two strongest teams. Compared with the 11th championship of Guangdong men’s basketball team, Liaoning men’s basketball team has won the championship of cba league only once, but the runner-up has won many times, which has also been criticized by many fans. Liaoning fans who are very unconvinced listed the past record of Liaoning team, and the time goes back to the national basketball championship in 1985. As we all know, cba league only has a history of more than twenty years. Here

According to the statistics of the fans, since 1985, Liaoning men’s basketball team has won 12 championships in many competitions, such as the National Basketball Championship, the National Basketball League, the National North-South Championship, the National Games, the Asian Club Cup, cba, Extraordinary 12, etc. From this figure, it has indeed surpassed Guangdong’s 11 championships. In fact, just from the data point of view, it can’t explain too many problems. After all, the glory created by our predecessors has become.

On the afternoon of November 4th, 2022,Under the guidance of Futian District Talent Bureau, the Smart City Special Session of Zhichuang AI-AI+Industry Summit sponsored by Shenzhen Artificial Intelligence Industry Association, Gongdadi Innovation Technology (Shenzhen) Co., Ltd. and Guangzhou Yingma Information Technology Co., Ltd. was successfully held.

The talent development activity of "Zhichuang AI" is one of the series of activities of "Endeavour New Journey to Spend Talent Day" in Futian District in 2022. It gathers professionals from enterprises in artificial intelligence industry, focuses on AI industry ecology and artificial intelligence industry chain, shares cutting-edge perspectives and talks about new opportunities for artificial intelligence development. With the theme of "Smart Convergence into a City, Winning the Future", this forum focuses on the smart city field, and faces software developers, system integrators and hardware providers in smart city transportation, urban management and other fields, bringing together enterprise representatives and industry elites with AI intelligent upgrade requirements, and connecting upstream and downstream business opportunities, industrial landing experience and other all-round resources to jointly explore the development direction of urban scene application.

Zhao Cong, CEO of Gongda, Liang Hongbo, General Manager of Yingma Technology, and Lang Liping, Shenzhen Artificial Intelligence Industry Association delivered speeches for the event; Li Sunan, Senior Marketing Director of Gongda, Lu Zhitao, Director of AI Scene Application Division of English Code Technology, Yan Weijie, Manager of Qianshitong Solutions Department, and Liu Rongjie, Product Director of Gongda attended the event and delivered speeches, and had in-depth interactive exchanges with business representatives and industry elites in the smart city field on the key technologies, scenes and needs of smart city development.

This activity focused on key technologies and fields such as visual AI, intelligent transportation, intelligent security, AI computing power, etc., and invited more than 60 enterprises to participate in the in-depth discussion of hot and difficult issues in the construction and promotion of smart cities. At the same time, the live broadcast of the event attracted nearly 3,000 participants. Through this activity, participating enterprises share their experience in AI construction of smart cities, combine the digital and intelligent transformation needs of their fields, make all-round docking of related resources, jointly explore the development trend of smart cities, and jointly promote the high-quality development of artificial intelligence industry.

"Nine -ball Queen" Pan Xiaoting, the value of more than 1 billion is conservative. Today, the age of 39 is still single and is still a big daughter of Huanghua.

She once announced her own spouse selection criteria:

1. The face value is high, and the height cannot be lower than 1 meter 76;
2. Mature and stable, you must have your own career;
3. To pursue her actively, if you don’t take the initiative, you would like to miss it;
4. Don’t have filial piety.

Netizens shouted directly: It’s too difficult to take off the order!

There is a saying in the billiard industry called "Men have Ding Junhui, and women have Pan Xiaoting."

Pan Xiaoting is the first player to win the World Championship in my country’s billiard industry. He is the holder of the 9 -ball World Championship, which is therefore called the "Nine Ball Hou".

Pan Xiaoting was born in Jining, Shandong in 1982. His father was a billiard enthusiast and opened a bill for a bill. Due to the excellent ball skills, it is called "Pan Yi".

In Pan Xiaoting’s childhood, he did not show any interest in billiards, but was interested in painting.

She drew perseverance, and one painting has been for several years. Art has also become her dream.

Until college, Pan Xiaoting rarely played billiards. Occasionally, Pan Xiaoting was in a bad mood because of conflicts with his classmates.

As soon as home, she picked up the club of the table to vent her emotions.

What she and her father did not expect was that although Pan Xiaoting had not practiced, she scored several balls at hand.

This is obviously a talented player.

However, at the time, Pan Xiaoting didn’t think too much, and his father only hoped that his daughter could grow up happily and did not deliberately train billiards, but occasionally played.

During the college entrance examination, Pan Xiaoting, who has always liked painting, applied for art colleges. Unexpectedly, it was fell on the list.

For a while, Pan Xiaoting lost his direction in the future and doubted himself.

Fortunately, after repeated consideration, Pan Xiaoting decided to learn billiards with his father.

For her daughter’s future, her father began to train her strictly.

Regardless of the winter or cool summer, Pan Xiaoting play billiards for more than seven hours a day. For a month, it can only take a break, sometimes only half a day.

What makes Pan Xiaoting feel more hard is that in the summer, even the hottest weather, the fans are not opened during training. Pan Xiaoting often sweats hotly and has to continue training.

In winter, even if your fingers are frostbite, you still have to practice.

For her, occasionally wanting to be lazy, she is not allowed.

A boy is even difficult to endure this training intensity, and it is a flower girl.

During that time, Pan Xiaoting thought more than once that her father didn’t love her, so she had a hard time to eat her so much.

Fortunately, Huang Tian lived up to the painstaking people, and Pan Xiaoting’s dedication got the return.

In 1998, Pan Xiaoting’s father, Pan Jian, took Pan Xiaoting to Beijing to participate in the first nine -ball women’s opening game.

In Beijing for a month, in order to save money, the father and daughter lived in a 15 -dollar air -raid hole, eating 10 yuan of fish flavor shredded, and life was very difficult.

Fortunately, the two were not very bad. Pan Xiaoting won the championship in one fell swoop and won 4,000 bonuses.

My father was proud of his daughter, and asked what his daughter wanted to eat?

Pan Xiaoting said excitedly:

"Dad, I want to eat Beijing roast duck!"

Pan Jian Shuang agreed quickly and immediately took her to Quan Jide.

As a result, the father and daughter opened the menu and looked at them immediately!

A roast duck, it costs 156 yuan!

Although the fragrance of roast ducks made Pan Xiaoting sorrowful, she still felt very distressed and pulled her father’s corner and said: "

"Dad, let’s forget, let’s take a look elsewhere."

Pan Jian said to his daughter:

"Girl, eat it when you come, let’s order half!"

So Pan Xiaoting ate it quickly. At that moment, Pan Xiaoting felt her father loved her again.

In order to make parents live a better life, Pan Xiaoting worked harder to train. And on the road of billiards, she also opened all the way.

In 2000, Pan Xiaoting won the championship again in the national sports competition. In the same year, she won 6 national championships.

Since then, Pan Xiaoting has opened a journey to win.

In 2007, Pan Xiaoting won the world championship in the World Championship final and became China’s first billiards world champion.

In addition to getting bonuses, Pan Xiaoting also made a lot of advertisements and received a lot of endorsements. It is estimated that the value is conservative!

There is no doubt that Pan Xiaoting is already the pride of his parents in his career. However, on personal problems, Pan Xiaoting made his parents very concerned.

At the age of 39, she is still single and is still a yellow flower girl.

During the period, although he had a scandal with Ding Junhui, Pan Xiaoting showed that he was just a good friend!

Today, Ding Junhui’s children will make soy sauce, and Pan Xiaoting is still alone.

For the other half, Pan Xiaoting also announced her request:

It seems that it is not high, but it is not found. It is also impressive. Is it really not good for a boyfriend?

In addition to the "Nine Balls" Pan Xiaoting, there is also a particularly excellent woman, which is nearly 40 years old, worth 10 billion yuan, and is still single.

She is a woman who refuses Ma Yun three times, currently the director of Yunfeng Fund, Li Ying.

Li Ying graduated from the Massachusetts Institute of Technology. Because of his high IQ, he was too good, and was appreciated by Ma Yun.

However, Ma Yun invited the other party to join his company three times, but he was rejected.

Until the fourth time, Li Ying promised to serve as a director of Yunfeng Fund.

Today, this strong woman is nearly 40 years old, with tens of billions of dollars, but still single.

In this regard, some netizens said:

Such a woman is not good at climbing, and it is a kind of sadness to be stronger than no one.

Some netizens said:

If you have money, why do you have to get married? Single is cool for a while, and he has been single.

How do you think about this? Welcome to leave a message. The picture comes from the Internet, invading and deleting.

Because of the impact of epidemic and economic transformation, the population of third- and fourth -tier cities is flowing. Many of these migrant workers who returned from Shanghai, Shenzhen and other places are highly educated groups. In the golden area of ??third- and fourth -tier cities, they purchased houses in the "rich area", not only high -quality school district houses, but also supporting and greening are comparable to high -end houses in large cities. The houses in these high -end communities have risen first. Compared with other communities, the "hot island" effect appears, which is a lot higher than the surrounding house prices.

First, return home to snap up high -end houses

Many people who return home sell houses in big cities and buy a high -end house in their hometown. They can take their parents to live together. If you go back to the outside, you will have a place to settle in your hometown. Someone was affected by the mortgage of large cities. A loan of millions of dollars in a house made their lives and work suffer a lot of pressure. Buy a house in his hometown, and there are still funds in your hand to start a business or use it for daily life.

Second, the family replacement school house of the provident fund loan

Most families with provident fund loans are groups with stable income. Now many cities have increased the amount of provident fund loans and reduced down payment. They can buy a high -end house with a small amount of down payment. People who lived in the old town or high -rise houses were currently replacing high -quality school district houses. Therefore, high -end communities in third- and fourth -tier cities have recovered and rose against the trend, forming a sharp contrast with the surrounding second -hand housing.

Third, the scarcity of resources and the superiority of the location

Most of the "rich people areas" in third- and fourth -tier cities are mature communities built by large -scale housing companies that have been stationed before. From design style to supporting facilities are first -class. Now, many large real estate companies are far from the third and fourth -tier property market. It is difficult for local small development companies to have such a large handwriting, so it is particularly popular. The "rich area" is not only high in house prices, but also the local group is also rich or expensive in the local area. Therefore, house prices do not worry about selling the road.

From the trend of the property market this year, it can be seen that the rise and fall of the same city is blurred. So many favorable introduction, most of the property market is still not shocked. There are three changes:

01, the population continues to flow, but the house price is very strong

The phenomenon of the population of third- and fourth -tier cities is very common, and most of them are going out to make a living. If you say that Anjia Real Estate, you will choose to return to his hometown to buy a building. After all, house prices in large cities are high, living costs and housing costs are also high, and they can’t afford it. Therefore, many people will come to buy a neighborhood with good money outside. After all, Ye Luo will be rooted in the future, and now he will be filial to pick up his parents to life in the city.

02, interest rates have been reduced sharply, but most people do not buy a house anymore

Recently, with the introduction of the measures and interest rates, although the property market has stabilized and selling the building without panic, the transaction is still unconventional. Many third- and fourth -tier cities have no imagination scenes, and buyers are silent. Many families already have plans to buy a house, and the down payment can be available, but they are still watching and waiting. High -end communities are relatively hot, many people can’t afford it, housing prices in other areas are also falling, and few people buy it.

03, the vacancy rate increases, but the speculators do not throw the house

At present, the vacancy rate of third- and fourth -tier cities has increased by up to 30%. Many families have unstable income because of the high cost of housing. Therefore, when they return to the countryside, the house cannot be sold. There are also couples who work in the field. The speculators and groups of real estate have good housing in their hands, do not rent nor sold, and have no throwing house. Perhaps there are fantasies about the future property market.

　　Original title: 2020 "The people of Shanghai went to Shanghai," launched 20 special tourism routes+20 cities good events, which one do you like?

　　The Shanghai Culture and Tourism Bureau sponsored the "Shanghai People’s Going to the Shanghai event since the month of 2020. 19. China Tourism Day starts the date of the city. Many fine lines and waste management activities. The annual activity abstract and review, and in order to better launch a new event in 2021, revealing a new one, especially the "fashion capital, Shanghai magic" 2020 "Shanghai people go to Shanghai to Shanghai "Online competition.

　　Among the candidates of more than 3.00 candidates, more than 200 events. Cultural tourism experts repeatedly decided after selecting 20 special tourism routes and good activities in 20 cities. These final players will be appointed by the regional cultural travel agency in December this year. , Representing this line to participate in the speech, it has a detailed series with activities in the region. In the final jury, the media selection of the "Shanghai People’s Favorite Micro Shanghai Tourism Road" and "Shanghai’s Most Popular Cities" in 2020. "This is a good look at Shanghai’s finals and urban events. Shanghai is good!

　　Special tourist route

　　Baoshan District: Post -industrial fashion new way

　　Many people carry the memories of the old industrial factories. The old yard sparks in industrial reorganization, becoming the most avant -garde of the landscape of the industry. 3D printing of Smart Bay Branch Park brings together the Chinese Cultural Museum, the largest 3D printing bridge in the world, the pier and other art played red dot networks; the Shanghai Glass Museum has transformed from a glass furnace workshop to a magical change, colorful crystal glass world, China, China, China It is one of the three museums, not to be missed; the third -floor bridge sports cultural park, which was previously known as the Shanghai nitrate vacuum bottle factory, has become a new generation of red tide drift fist.

　　Baoshan District: Explore the villages north of Shanghai, "quiet" color

　　The national characteristics of the north gate of Shanghai -Luo Jing, Tangwan Town, starfish, bonuses, new land, and Yangqiao Village will build a "five villages scalable" rural revitalization demonstration zone. Tangwan’s most beautiful rural village road. The Shanghai New Road series comes from "fields, forests, roads, rivers, houses" this is a maternal cultural park hemerocallis flower, grass prostitute troubles, golden rice fields, adopt non -genetic technology entertainment; village in the village; in the village Starfish, Jellyfish Postal House Dating "Water Elf" Bath Water System Forest Oxygen Bar Spa, looking up at the sky and star camp, "crab accidentally meet" Baoshan Lake Yangtze River Crab, enjoying leisurely and pleasant rural life.

#270,000 elderly golden cases open##

The truth of this fact is that from 2009 to 2015, the old lady of Shanghai, Qian Mou, would abandon the husband who lost his ability to take care of his self -care in the hospital after paying some medical expenses during the hospitalization treatment, until the husband died alone. After the death of her husband, Qian still refused to go through the relevant procedures, and at the same time, he took the husband’s pension and accounted for himself.

On June 9, 2021, a case of fraud and abandonment of Qian, a public prosecution of the People’s Procuratorate of Minhang District, Shanghai, was held in the Minhang District People’s Court.

The truth of the case is very clear.

Some people think that pensions are in the country, and the national Tang monk meat, all Chinese citizens can eat, all of which are desirable. Therefore, it is not believed that the old lady of Shanghai Qian Mou is a criminal act. This view is particularly popular in the small and fresh meat little beauties. Because the little fresh meat and the little beauty thinks that farmers are reasonable to eat white food, everyone can not pay a penny social security, and they can be sits to share the social security provers for decades.

However, the understanding of farmers is extreme errors.

In the basic composition of pensions, all pensions of social insurance forms should belong to the private property of citizens who pay social security, and they are not owned by the whole society. In the basic pension of the national welfare form, [also known as the pension subsidy], that is, the country’s money from the city taxpayer to the farmer, the other social benefits that belong to the country to the farmers to the elderly.

Compared with the former, although it is also called pension, it is actually very different in nature. That is to say, the essence of social maintenance money is the private property of citizens who pay social security. They use their labor income to take out a part of their salary every month to invest in their future pensions, like bank savings. But more advanced than banks, these social property from citizens is managed by the state and has absolute security and insurance stability. The basic pension [also known as the pension subsidy for white hair to the farmers], the source of funds is not the citizen of the social security, but from the city’s hundreds of millions of taxpayers. Do not bear the tax responsibilities and obligations that every citizen should have, and the one billion farmers have no longer contributed a penny to the national fiscal tax for seventeen years. Therefore, these money -sweats from urban taxpayers have been distributed to farmers through the hands of the country. The money does not have the nature of private property, but has a social welfare nature.

Understanding the above principles, I understand that the old lady of Shanghai, Qian Mou, led her died of more than 270,000 yuan. The violent object was the private property of all social security citizens.

Similarly, those who do not pay a penny for social security, and those who have to pay the social security persons for decades of social security people are divided by farmers, which are those who eat white food selfish little fresh meat and little beauty. In fact Criminal behavior, they are public robbery, because their violations are the private property of the whole society who has paid social security for decades. But it is terrible that some people have committed guilty and do not know sin. Zhen Zhen has words that he is the savior of the peasant. He has called for robbery and plundering under the banner of speaking for farmers. As criminals, they have gone far enough on the road of illegal.

These pension articles videos are full of headlines. This fully shows that a large number of cyber criminals are active on the media network. They attempted to learn ancient bandits and live on the wealth of others by robbing others.

The opening of the old lady in Shanghai should let the small and fresh meat and little beauties who advocated robbery to calm the rational and rational girls. Please do not go further and further on the road of crime.

Since the reform and opening up, the urban management of Shanghai can be divided into three stages: the initial stage of reform and opening up to 2000, the construction management is cracked by solving the "three difficulties" (difficulty in transportation, housing difficulties, and environmental difficulties). With people -oriented, management as the first, safety as the first, to welcome the "Expo" event and consolidate "comprehensive management" as the main task; since 2017, it has entered refined management to make good use of the "three hearts and one needle" (embroidery -like " Carefulness, patience, excellence, and embroidery needle), build four beams and eight pillars.

After more than forty years of practice and exploration, Shanghai has accumulated rich experience in the process of dealing with various complex problems operating in large cities, and conducted a comprehensive exploration in the refinement of urban management.

In 2021, the Shanghai Housing and Urban -Rural Development Management Committee organized the writing "Exploration and Practice Series of the Construction of" People’s City "in the New Era". Strengthen the refined work of urban management and promote the exploration and practice of people’s urban construction. The book uses the four main "needle methods": rule of law, standardization, intelligence, and socialization (fourizations), combined with cases to detailed how Shanghai performs refined management.

In the chapter of the "rule of the rule of law" the "warning line" of urban management, the writing group cuts in from the legislative, revision, law enforcement and law popularization of the city management field in Shanghai, analyzes the application of the rule of law thinking in the management process, and confirms the construction of the rule of law. Fundamental role in urban management. We have edited some of the contents of this chapter, explained the necessity of rule of law in urban management, and selected one of the most representative cases in order to readers.

For a long time, Shanghai has always regarded the rule of law as an important cornerstone of the construction of governance systems and governance capabilities, based on the management needs of oversized cities, and continuously refining and optimizing the guarantee of legal systems.

In early 2021, driving into the Fenhu Daokou of the G50 Shanghai -Chongqing High Speed ??Speed ??and entering the boundary of Shanghai, Mr. Lin, who was sitting in the co -driver, received a text message- "The Regulations on the Administration of Shanghai Public Health Emergency" will be implemented on November 1, 2020. Everyone is responsible for preventing and controlling and controlling it according to law. Strengthen self -health management, strengthen self -protection awareness, wash hands, divide hands, use public chopstick spoons. Enter the airport, railway station, bus, subway and other public places to wear masks as required to maintain social distance ""

"It is illegal to wear a mask in Shanghai in public places." Mr. Lin turned his head and told his friends and took out the mask from his pocket.

The "Regulations on the Administration of Public Health Emergency" clearly stipulates that during the popularity of respiratory infectious diseases, entering public places should be worn in accordance with the requirements and maintain a social distance. Today, wearing a mask in public places is not only a civilized habit, but also a legal obligation that Shanghai citizens should adhere to.

How to use the rule of law thinking and the rule of law to regulate the public order of the city, so that the law can be dependent on, and the law is based on the law. It is an inevitable requirement and important content of the construction and management of modern cities. From the perspective of the refined goals of urban management, the accuracy and effectiveness of management methods should meet the basic requirements of standardized implementation, and the standardization of the means requires the establishment, sound, and perfect legal and regulatory system to enhance the particle size and refinement of legal resources With high rigorous rules and the spirit of the rule of law, it provides a solid institutional foundation and exquisite behavioral guidance for the efficient operation of urban management. On the one hand, we can rule the people and the people in accordance with the law, and use laws and regulations to restrict the behavior of citizens; on the other hand, in accordance with the right to rule, govern officials, regulate the behavior of government agencies and their public officials, and use laws and regulations to control the exercise of public power. It can be said that the process of continuous improvement of the rule of law in urban management itself is an important practice of the concept of "the people of the people’s city and the people’s city for the people".

The standardization of management methods is also conducive to overcoming the disadvantages of sports and empirical governance, and improving the long -term and stability of urban governance. The content of the standardized management methods also includes the clear division of the rights and obligations of various types of public affairs and the supply of public services, and the determination of organizational management and operating rules provides behavioral specifications for various governance subjects, and provides public rights of the public. Standards and basis, guide urban management laws and regulations to become social consensus and behavioral rules.

For the government, the rule of law of management methods lies in clarifying its responsibilities and their behavioral standards, accelerating the transformation of government functions, and promoting the original inherent leadership decision -making government to the legal decision -making government through the construction of the rule of law. For citizens, as the main body of the city, citizens have the right to also obliges to improve the literacy and legal awareness of the rule of law, can establish reasonable expectations for administrative processes and management effects, and achieve effective supervision of public administration. It can be seen that the rule of law is the core symbol of urban competitiveness and the dazzling business card for urban governance.

The ideal state of rule of law is "the law can be prohibited, and the law is prohibited without authorization." To achieve this goal, the lack of legislation, law enforcement, and law general law is indispensable. Especially for Shanghai with the inheritance of sea -faction culture, its regional culture itself has a basis for contract civilization.

Shanghai is the first city in the country to implement garbage classification. From July 1, 2019 to the present, it has formed a situation of Shanghai demonstration and onlookers in the country. For Shanghai, legislation is both the task required by superiors, but also the endogenous demand generated by garbage classification to a certain stage. Up to now, the "Regulations on the Management of Shanghai Municipal Lomitic waste" have been implemented for more than two years, and the garbage classification has entered the daily life of each Shanghai person. It shows the civilization of the city.

Case: Fine Management -Taking the "Regulations on the Management of Shanghai Municipal Links" as an example

From 2005 to 2010, the average annual growth rate of Shanghai’s domestic waste was about 3%, the average annual growth rate from 2011-2017 was 4%, and the annual growth rate after 2014 reached 5%. And the traditional garbage treatment method, whether it is incineration or landfill, will bring obvious problems: occupying tens of thousands of acres of land, mosquito flies fly chaotic, sewage overflows, smells of the sky, seriously pollute the soil and groundwater environment … The number of garbage is still threatening the lives of various wild animals, and the garbage in rivers and oceans invades the habitat of aquatic creatures, causing them to die by mistake and even species extinction. At the same time, the two evils brought by the waste incineration are one of the most deadly toxic substances on the earth. After the incineration is discharged and discharged, it can diffuse from a long distance. Once the pollutants enter the human body, they will stay for a long time and eventually cause cancer. "Garbage siege" has been "under the city."

Promoting garbage classification can effectively improve the efficiency of garbage treatment, reduce treatment costs, reduce land consumption and environmental pollution, drive circular economy, save resources, and turn waste into treasures, and have the benefits of social, economic and ecological aspects. However, in order to do a good job of domestic waste, we must change people’s behavior habits and require a long -term process. Refined governance of domestic garbage in other countries often go through decades or even longer efforts. Therefore, the legislative work of the garbage classification is not only the need to mobilize the entire force, but also the most powerful education and guidance of this work and the most powerful education and control.

On the basis of a large -scale questionnaire survey and full review, Shanghai people have reviewed and approved the "Shanghai Municipal Home Wurns Management Regulations" greater than January 2019. It is announced that it will be officially implemented on July 1, 2019. Enter the "hard constraint" era.

The legislation clarified several priorities in Shanghai’s garbage classification work. One is how to divide it? Shanghai has been exploring garbage classification since the 1990s. After several changes, in 2011, it was determined to be recyclable, harmful garbage, wet garbage, and dry garbage. During the review of the regulations, the Standing Committee of the Municipal People’s Congress designed a set of questionnaires for the general public, and the results showed that most citizens expressed their recognition of the "four -point method".

Shanghai domestic waste classification and launch guide

Who will control it? At the three levels of the city, district, and streets, the regulations stipulate the management model of "combination and block", and clarify the work content of the street office and the township people’s governments. One by one. For example, units and individuals who generate domestic waste are the responsible subjects of classification and distribution. They should put domestic waste to the corresponding collecting containers; each launching point shall establish a classification and distribution management responsible person to clarify their rights and obligations; For garbage, the receiving unit can refuse to receive it. If it does not make corrections within the time limit, it can be fined.

The third is how to do the source reduction? The regulations include specific matters including promoting product packaging materials and reduction of express packaging. For example, hotels must not take the initiative to provide disposable daily necessities, catering service providers and catering distribution service providers must not proactively provide free disposable chopsticks, puffing and other tableware. In Shanghai, when using APP such as "Hungry" or "Meituan", each merchant must provide special tableware options and give reminders to "provide on -demand".

Fourth, how to achieve "closed loop" management? The regulations strictly standardize and transport and transport, and clarify that the receiving units must use special vehicles and ships to implement closed transportation. Realization of the whole process.

After the "Shanghai Municipal Domestic Waste Management Regulations" was officially implemented, a public account article entitled "A picture to understand Shanghai’s domestic garbage classification" was crazy "swipe the screen" in the circle of friends. Someone teased that the "magic people" was "mad" by the garbage classification. Every morning, when they went out, they had to accept the soul torture of "what garbage was".

Mobilization and ridicule, but if you go to the community and ask "whether the garbage classification is good", even the seventh or eighty -year -old grandma will answer you: "Okay! Now the environment is so serious, Allah is obliged to contribute to environmental protection." Since the implementation of more than two years, garbage classification has entered the daily life of every Shanghai people. Everyone is proud of "division", ashamed of "indiscriminate".

Observing all corners of Shanghai, you can find many places that are changing because of garbage classification: Located on the coast of the East China Sea and 70 kilometers from the southeast of the city center -this "digestion" of about 50%of the domestic garbage terminal treatment in Shanghai The landfills have become the ecological protection display window of green surroundings; Xinyixiu Village, which has achieved "wet garbage cannot be out of the community", Aunt Hou voted to the wet garbage in the community’s trash tank, and the intensive processing of intelligent equipment was treated with concentrated treatment 4 hours later, it became organic fertilizer, and was taken home by Aunt Hou to raise flowers. At the Century Lianhua Luban shop after the "Plastics Limit Order", the counter was carefully prepared on the counter. Packing for customers to use …

Shanghai Old Port Ecological Environmental Protection Base is the world’s largest waste incineration plant and medical waste disposal facility

Xinyu Liu Village "Wet garbage does not get out of the community"

The changes that occurred in factories, communities, supermarkets, and landfills are the true portrayal of the participation and control of the whole people. As of the end of 2020, Shanghai has initially established a full -process classification system to achieve 100%harmless treatment of domestic garbage. Both residential and unit domestic waste classification standards have doubled more than 95%, and the recycling rate of domestic waste resources has reached 38%. Garbage classification makes Shanghai more livable and more temperature.Please clickhereOr scan the code to buy to understand the exploration of refined city management in Shanghai: