"Commando-style" tourism is still hot, and another way of tourism has quietly emerged, that is, "City Walk", a city walk.

The city walk originated in London, England. Tourists visit the city on foot under the guidance of professional tour leaders. After walking, everyone will exchange ideas, so this is not only a way of traveling, but also a kind of knowledge sharing and socialization. There is only one keyword: slow, walk slowly, look slowly, and feel slowly. Recently, this kind of relaxed travel style has been on the rise, and many people say that this is the real deep tour.

Of course, I don’t have any problem with the "special forces" travel mode, but I thought it was impossible to keep it hot for a long time. The overdraft of super physical strength and the exhaustion of punching cards are destined to make this kind of travel only a short-lived game for lively young people.

Therefore, the rise of city walking coincides with its meeting, and it is also a re-examination and return of the significance of travel. The so-called travel must not be a cursory tour, it must not be a rush to punch in, it must not be getting on the bus to sleep and getting off the bus to take pictures, but observing and understanding with curiosity and discovering the multifaceted nature of the city. On this road, we can see the mountains and water, see all beings, measure the earth with our steps, and look for unique human geography in the city. This, perhaps, is the deepest meaning of travel.

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

This thing, everyone is not strange?

Yes, it is a breathing light.

It is used to remind the user to have a prompt lamp for notview information. With it, we only need to look at it, you can know if there is any information just now.

As a function of your mobile phone, the most touching function. But when it’s, it’s hard to be eaten.

At least in my impression, there is a suggestion on the Nokia function.

(Nokia E5)

In more than ten years, we don’t know, witnessed the classic cases of a lot of tips.

Like Samsung, under the on-screen panel, a secluded tips can be said to be the most traditional design.

Meizu ring breathing lights, integrating with Home, elegant and exquisite.

When there is information, the entire ring is slowly released, and slowly extinguish, like a nuclear reactor of the Iron Man chest.

In addition to the headless brand mobile phone, even hundreds of dollars of functional machines, there are also running horse breathing lights.

This, the iPhone user next door does not agree.

Some people open the iPhone, actions, and change the back LOGO to the breathing lamp.

It can be seen that people have a manner that the breathing lamp is not limited to its own function.

However, the good view is not long, with the arrival of the full screen, the border of the mobile phone is getting narrower and narrower, and the living space of the breathing lamp is squeezed.

(IPhone X Liu Haiping)

Of course, this is half a pseudo-proposition, because we can still see that there is a breath lamp in the side of the mobile phone.

At least, this tests the industrial design, and cost of the manufacturer.

(Red rice 10x breathing light built into the border)

Secondly, the presentation of the information big bombings, mobile phones have not received incoming calls and text messages, but also have to receive various app notifications.

People have also begun to change the usage habits of mobile phones. If there is something, there is nothing to illuminate, and the mobile phone almost "long" in the hands of people, the probability of missed the information is getting lower and lower.

Of course, the most deadly or the popularity of the OLED screen, let the "interest screen are always bright" into mainstream functions. Call or information will have a corresponding icon display.

This can be more intuitive than the breathing light.

This, the rice bowl of breathing lights directly.

With the function of smartphones, design homogenization, "interest screen display" is nothing, replacing the breathing lamp, has become a breakthrough in the manufacturer to show the brand identity.

With many factors, in recent years, we are more and more difficult to see, there is a breather’s mobile phone.

But many old users are unknown until they have changed new mobile phones, they found no breathing lights. Many people call online to let the manufacturers add the breathing lamp back.

However, the breathing lamp does not completely disappear, it is equipped with another form on the phone.

For example, Huawei P50 PRO is used, an electrochromic material is used. As the name suggests, it is a material that will discharmatically.

When the phone is called, the p50 Pro rear cover will energize, and the effect of breathing light is flashing.

There is also a fascinating, at this year’s Flyme9 conference, the MX2 classic circular breath lamp, and the vocal screen displayed.

But these are not real breathing lights, I want to say who play lights, or I have to read OPPO.

To say that OPPO, there is a lot of classic breathing lights. 7 years ago OPPO Find 7 skyline breathing lights, so far is the design of Find loyalty.

(OPPO Find 7 breathing light)

As well as the N3 star cyclic breathing lamp, you can get a classic breathing lamp.

(OPPO N3 breathing lamp)

This time, OPPO has brought new designs, Reno7 Pro "Star Ring" breathing lights.

This time, OPPO took the breathing lamp to the edge of the rear module.

The star cyclic ventilation light has a variety of setting options, such as charging, and the call is flashing, or even as a game atmosphere.

And, we can also specify the app to turn on light efficiency.

In different modes, Reno7 breathing lights have different colors.

Corresponding to the star cyclic breathing lamp, it is like a meteor shower. This back cover uses the space-grade star rain, and is precisely engraved on the star diamond glass.

Will a Dow Meteor, eternal engraved on the back cover.

Reno7 Pro uses a right angle design, only 7.45 mm thickness, the weight is controlled by 180g, which can be said to be kneaded.

OPPO is in such a thin body, it is stuffed a 4500mAh battery, and those who say that the light is not long, it can be said to be faced.

What’s more, Reno7 also supports 65W flash, and battery anxiety can be said to be worship.

The screen is a 6.55-inch OLED screen that supports 90Hz refresh rate. Due to the use of the straight screen, the screen accounts for 92.8%, and the border is only 1.55mm.

As a direct screen of the game, it is said that it is taken.

In photography, OPPO is directly to the Reno7 series, and the title of "Portrait Video Master" is not difficult to guess. The direction of this special attack is photography.

The front lens is 32 million pixels, which uses a new, sensor IMX709 customized with Sony depth.

This sensor integrates, OPPO self-developed RGBW image fusion units can have better photosensitive ability and color reducing capabilities.

Not only in the absence of light, take a gratifying self-timer, even if the backlight shooting, it can be very clear.

(Shooting shot)

Reno7 Pro is equipped with 50 million pixel main photos, and the sensor uses a new IMX766, and the effect of larger sensors is obvious.

From the main photographing photos, it can be seen that both the details or the overall brightness, Reno7 Pro has been controlled very good, and the picture color is very good.

(Main shooting)

Reno7’s super wide angle view range, reached 118.9 °, and there is still a bit worried about edge distortion at the beginning.

But actually shooting, I have more considerable consideration, Reno7 is still very good to correct the distortion.

And under the tuning of OPPO, the picture, color is consistent with the main experience.

(Super wide angle shooting)

In terms of performance, the processor of Reno7 PRO is Tianzhu 1200-Max, as well as UFS3.1 memory, LPDDR5 storage blessings.

Machine brother also tested the game of "King", after opening the ultra-high frame rate mode, half an hour’s average frame rate 88.4 fps, can be said to be very stable.

On this basis, OPPO is equipped with "Super Lightning Start 2.0", combined with "game pre-update 2.0", can directly skip the game update, one button is black.

Can’t help but say, mainly the return of the breathing light, let people live "Lan Qing back".

But as for the future, the breathing lamp will not completely disappear, I also can’t say it.

Before, there was a netizen to say why it is not invented to remove the mobile phone battery so that the mobile phone is not electricity to change the battery, saving more time.

Many old netizens, including the opportunity to see, the heart is both bitter, but also helpless.

For so many years, do you have to go far from our headphones and detachable batteries?

If the child later, I suddenly asked me: "Why light the screen can you know if there is any information. Directly install a message tips, isn’t it good?"

I may really don’t know how to return him, it is possible, this is the Renaissance …

New youth

Always accompany you all the way

At 3:40 pm on November 29, the women’s basketball competition was held in the large playground, and the School of Mechanical and Electrical Engineering VS Materials and Environmental Engineering College.

At the beginning of the game, the basketball athletes of the Mechanical and Electrical Institute took the initiative to pass the ball with a good and skilled movement, and to force the rebound. Our team members quickly entered the state, and they were all heroic. On the court, you are fighting for me, you attacked me, and you have a skilled pitching. The pitching movements are handsome and neat. At the same time, the cheerleaders also shouted outside the court, and the atmosphere of the court was very active. In the end, the School of Mechanical and Electrical Engineering won the game at 25:19.

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After this basketball game, it not only enriched the students ‘extra -curricular life, but also strengthened the students’ awareness of exercising and solidarity and cooperation, allowing students to relax their body and mind in the intense study life, and felt the strength and warmth of the group’s groups. Essence I hope that our women’s basketball team members will be overwhelmed all the way in the next game and break the waves to win a better ranking!

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