Recently, the "Made in Chongqing" medium and large SUV, which has received much attention, has asked for a new M7, and its monthly order has exceeded 60,000 units. On October 24th, Sailis Auto Smart Factory ushered in an open day to explore the whole process of the birth of high-selling cars.

Sailisi automobile wisdom factory. Photo courtesy of Cyrus

Sailisi Automobile Smart Factory is located in Shapingba District. Construction started in 2020, with a total investment of about 4 billion yuan. As a smart factory built according to "Made in China 2025" and Internet of Things standards, it has an intelligent collaborative system "digital brain", which includes four major processes of vehicle manufacturing and some parts production areas, and has the characteristics of intelligence, digitalization and flexibility, and can be used to produce high-end intelligent networked cars.

Sailisi Automobile Smart Factory, as the production place of the new M7, has the whole process workshop of stamping, welding, painting and final assembly. Into the factory, highly automated production lines, robots and workers work together, and every detail shows the technology and rigor of intelligent manufacturing. It is also from here that the whole process of vehicle production is completed and delivered to consumers with high quality.

Workshop site. Photo courtesy of Cyrus

According to reports, among the four major process workshops, the stamping workshop adopts the world’s advanced automatic production line, and the welding workshop is equipped with 344 robots, realizing 100% automatic welding and gluing. The painting workshop adopts the world’s leading environmental protection materials and automatic spraying technology to ensure the high quality and efficient spraying of the car body. The assembly workshop integrates a variety of advanced technologies, from the interior to the chassis, and then to the final assembly, which has achieved efficient and high-precision production.

Workshop site. Photo courtesy of Cyrus

In terms of quality control management, Sailis Auto Smart Factory has adopted a strict inspection system and adhered to the principle of "one car and one physical examination" to realize 100% automatic inspection of each component, "one in and one out" and full-time full-scale inspection. As a local new energy automobile enterprise in Chongqing, Sailis Automobile Smart Factory has also adopted a variety of energy-saving and environmental protection measures, renewable resources and recycling technologies to achieve zero emission and pollution, and ensure that it can truly meet the environmental protection process standards.

The relevant person in charge of Celeste Automobile Smart Factory said: "As the latest masterpiece of Celeste Automobile Smart Factory, Wenjie New M7 has not only achieved new heights in intelligence and environmental protection, but also achieved a comprehensive upgrade in quality control. From the four major process workshops to quality control management, the factory will ensure the delivery ability of’ high quality and high quantity’ in all aspects. " (Yu Mei)

Text | Photon Planet Wu Kun Proverbs

Editor | Wu Xianzhi

A few days ago, the major personnel changes in Ali Games, which once caused a lot of uproar in the industry, came to the fore.

Zhan Zhonghui (flower name: Dingdang), the head of Linxi Mutual Entertainment, a game brand under Alibaba Group, issued an internal letter saying that he and Chen Weian will step down at the end of the fiscal year (March 31), and his post will be taken over by Zhou Bingshu, the producer of "Three Kingdoms Strategic Edition".

The internal letter mentioned, "With the gradual improvement of the talent echelon, Linxi’s young people have grown rapidly and have been able to shoulder the heavy responsibility of leading Linxi to continue to develop. By the end of this fiscal year (March 31st), Lao Chen (Chen Wei ‘an) and Chun Jiao (Liu Jiao) and I will officially step down from the Class Committee and hand them over to the new team led by Bing Shu. I believe that the new team can better face the future, practice Linxi’s research and development concept more solidly and take Linxi to a new height. "

It is worth noting that Dingdang and Chen are both veterans of Jian Yue Science and Technology, the predecessor of Linxi Entertainment, while Chun Jiao joined the partnership company Tianjin Jinfan Bailing in April last year, and their resignation means the exit of Jian Yue’s old team.

Since the mutual entertainment with the "Three Kingdoms Strategic Edition" hit the volume of Ali games, there was no new tour with enough weight. This also leads to its position in the whole market is always high or low.

Although we are not sure about the real reason for Jian Yue’s retirement, we can be sure that the "new height" of mutual entertainment needs new explosions to touch.

Ali game seeks change.

Mutual entertainment or Ali games, whether from the inside or outside, have long wandered on the edge of the core circle.

In 2014, Ali integrated its mobile game platform with UC Jiuyou and established Ali Games, which belongs to the big entertainment sector. At that time, in the large entertainment sector, the game business was not eye-catching.

Ali Games did not make many achievements in business in the following years, and most of them focused on the distribution and agency of IP mobile games, such as the TV series IP adaptation mobile game "Fire Like a Song" launched in 2018 and "Wu Dong Gan Kun" linked by drama and travel. Even in the course of its development in official website, the explosive proxy game Traveling Frog in 2018 will be the first stop.

The change stems from the fact that in 2017, Ali spent 1 billion to acquire Jian Yue Technology founded by Zhan Zhonghui, the former COO of Netease, which strengthened the self-developed genes in one step and started the shift from issuing and acting as an agent for IP games to self-research. In 2018, Ali Games launched a self-developed MMO "The Land of the Wind" to initially test the water and research the game. In 2019, "Three Kingdoms Strategic Edition" was born. On the first day, it reached the top of the App Store for free, and in less than two months, it gained more than 300 million monthly water.

In September 2020, Ali Games was upgraded to an independent business group with mutual entertainment parallel to the great entertainment, and then two games, The History of the Three Kingdoms, Warchess Edition and Forest Country, were launched. It is worth mentioning that these two games came out in 2023. Before last year, the action of mutual entertainment focused on the overseas release of the "Three Kingdoms Strategic Edition", which greatly drained the commercial value of the "Three Kingdoms" IP.

The combination of the IP of the Three Kingdoms and SLG, which emphasizes strategy, is really a "golden egg". Even in 2023, the Strategic Edition of the Three Kingdoms still contributed 69.5% of the income for mutual entertainment. However, at the moment when high-quality games emerge in an endless stream, one trick can’t be eaten all over the world. According to Sensor Tower, mutual entertainment ranked 13th in the revenue of China mobile game publishers in January this year, which has dropped out of the top 10.

As the N in the "1+6+N" system, the explosion after the IP of "The History of the Three Kingdoms" makes the mutual entertainment of Linxi show signs of marginalization again under the star business such as rookie, box horse and 1688, even from the perspective of the game industry.

As we all know, the strategic SLG such as "Three Kingdoms Strategic Edition" is a typical big ARPU game, and the player’s basic disk is not large, which leads to its low volume in the majority of players’ circles, so that some players don’t even know that Linxi Entertainment is a subsidiary of Ali Group.

More importantly, low DAU games need long-term spending to attract fresh blood. "Three Kingdoms Strategic Edition" has won the number one mobile game purchase list for many times, which means the huge purchase cost of ensuring the product flow and the lack of high-quality traffic in the Ali system.

Looking back at its history briefly, Ali Games was originally established by combining the mobile game platform with UG channel, aiming to build a distribution platform for the game, which is extremely dependent on traffic. However, eight mobile phone manufacturers, including OV Huawei, set up a hard-core alliance to restrict third-party application stores from the bottom of hardware, which is tantamount to a fatal blow to Ali’s channel business.

Moreover, Ali’s core e-commerce business is a big consumer of traffic demand, as is the game. Under the huge cost of buying and the allocation of traffic resources, the game business is doomed to not get too many resources, which may be one of the reasons why it is difficult for Linxi to have a second explosion.

Under this circumstance, it is not surprising that Ali’s game, which is seeking change, chooses to trade in the old for the new, so that Zhou Bingshu, who made the first explosion, is at the helm.

Internal three-nation killing?

The alternation of old and new is a common occurrence, but in today’s Ali, it adds a bit of enterprising meaning.

On December 20, 2023, Cai Chongxin, Chairman of the Board of Directors of Alibaba Group, announced the reform of comprehensively promoting the rejuvenation of cadres in a full letter. He said in the full letter: "Next, we will fully enable young management teams who have been trained at the grassroots level to create their own innovative environment for young people." Immediately after the core management of Taotian changed blood, Wu Jia, Chen Weiye, Wang Tingxiang and many other post-80 s young people took the lead. At the beginning of last month, Yu Yongfu, Chairman and Hungry CEO of Local Life Group, announced that he would step down from his management position on March 31, and his successor was the post-80s generation.

From this aspect alone, the personnel changes of mutual entertainment can be seen as a part of Ali’s younger management reform. After all, Zhou Bingshu, who succeeded him, was also born in the 1980s. There are only more signs that there is an internal struggle in its reform.

A person close to Ali said that Jian Yue had been marginalized for a long time in mutual entertainment, and the old people headed by Zhan Zhonghui had long been put on hold by the new generation represented by Zhou Bingshu. Perhaps, after the handover of the old and new teams, it was followed by a big change of blood from top to bottom.

As for the reasons behind it, some sources said that the internal discord between Linxi and Linxi originated from the "Three Kingdoms Strategic Edition". It is understood that Zhan Zhonghui tried to cut this project when the game was established, and the reason may be that the core gameplay is too similar to Netease’s "Land of the Land".

In fact, Netease sued the former for copyright infringement and asked Linxi to stop the game. In May last year, the court ruled that the infringing content of The Three Kingdoms Strategic Edition needed to be deleted or modified, and compensated Netease for 50 million yuan, but the court rejected Netease’s request to stop operating The Three Kingdoms Strategic Edition. Linxi said that "some of the contents in the judgment will not be recognized and an appeal will be filed", which shows that the rip-off of copyright is a "psoriasis" that Linxi can’t get rid of.

As a result, the dilemma of "no follow-up" is becoming more and more prominent, and it is naturally necessary to work together internally. However, since Linxi Entertainment became an independent business group in September 2020, Yu Yongfu, the former chairman of Gaode Group, who was in charge of the subsidiary, was not familiar with the game business, and he also took over the local life business in July 2021, which may have caused Linxi to lack a strong voice to move forward.

In January of this year, Fan Luyuan, chairman and CEO of Alibaba Entertainment, was in charge of mutual entertainment. He not only served as the leader of Ali’s game business leading group, but also experienced the launch of games such as "Three Kingdoms Strategic Edition" and "Three Kingdoms Fantasy Mainland" during his tenure. His return is like several arhats who took over Ali last year. The first priority is to do a good job of "anchoring the sea".

Now the replacement of the person in charge of the mutual entertainment business has come to an end. When the granularity is completely aligned, what Ali Games is seeking is further growth, that is, launching a new tour with enough influence as soon as possible.

end

For insiders, mutual entertainment was once regarded as the "second Netease".

First of all, most of the core leaders of Linxi Entertainment were born in Netease games. In addition to former Netease COO Zhan Zhonghui, Chen Weian was the vice president of Netease and the general manager of Netease Blizzard Joint Venture. Zhou Bingshu, who will take office on March 31, is also an old man of Netease. He once worked as a game planner for Netease.

Today’s new and old alternation, do we regard it as Netease in the 2010 s replacing Netease in the 2000 s, or the Netease of Ali games?

In Fan Luyuan’s letter of taking over the mutual entertainment of Linxi, he mentioned that the future direction of Linxi’s mutual entertainment is: embracing AI, globalization, producer-centered system, and insisting on R&D leading business. Mutual entertainment will give enough support, space and incentives to potential young producers.

At first glance, this is similar to Netease’s small team development model. At the beginning of this year, Tencent also released the "Bamboo Shooting Plan" to support small and medium-sized development teams. It can be seen that vertical independent games will be the main theme of the game industry for a long time to come.

In any case, in the face of 2024, which is destined to be a big year for the domestic open world, it is impossible to continue the old gods with the golden egg of the Three Kingdoms.

As soon as the dragon looked up, news about the new tours of Tencent, Netease, Kuluo, Lilith and other manufacturers in the open world was constantly exposed. Or it’s possible to set up a project to raise a gun or start testing soon. A battle for the attention between players has already started, and the mutual entertainment of Linxi has lagged behind for more than a year.

　　The picture shows Shangzhuang Village, Chencao Township, Jian ‘an District, Xuchang City, Henan Province. The electric translation sprinkler is watering the wheat field. Xinhua News Agency reporter Feng Dapeng photo

　　Water is the foundation of human existence. March 22nd is the 26th World Water Day and the beginning of the 31st China Water Week. This year, the United Nations decided that the propaganda theme of "World Water Day" was "Borrowing force of nature to protect green mountains and green rivers". The propaganda theme of "China Water Week" is "Implementing national water-saving actions and building a water-saving society". What measures and effects does China have on water conservation?

　　■ There are many activities in love the water.

　　In the south of spring, willow branches are swaying and flowers are blooming. On March 22nd, the activity of "Taihu Cup Looking for the Guardian of Rivers and Lakes Around" was held in Nanjing Youth Olympic Cultural Park, Jiangsu Province. "I witnessed with my own eyes that the river at my doorstep is getting cleaner and the environment is getting more and more beautiful." Ms. Liu, a citizen who came to participate in the event, said, "I hope I can do something."

　　Many cities take World Water Day and China Water Week as an opportunity to carry out publicity and experience activities and contribute to the construction of water-saving cities.

　　Zhejiang Hangzhou Water Group launched the "Water Supply Open Day" to help citizens understand the production and operation of urban water supply and drainage, environmental water distribution and maintenance and other related projects, and the staff of water supply enterprises answered questions from zero distance.

　　Wuhan Jianhe Middle School in Hubei moved the geography class to the Yangtze River levee. The teacher scooped up two bottles of river water, so that the students could watch the color and smell it and have a quiz on water knowledge.

　　■ The industry can’t save water less.

　　In recent years, from agriculture, industry, service industry to urban domestic water, the utilization efficiency and benefit of water resources in China have been steadily improved. According to the data provided by the Ministry of Water Resources, from 2012 to 2016, the water consumption per 10,000 yuan of GDP and industrial added value decreased by 25.3% and 26.6% respectively, and the effective utilization coefficient of farmland irrigation water increased from 0.516 to 0.542.

　　The agricultural sector, which exceeds 60% of the total water consumption in the country, has achieved remarkable results in water saving. "I used to water the land, but now I water the seedlings." In the greenhouse of Gobi Agricultural Industrial Park in Suzhou District, Jiuquan City, Gansu Province, fist-sized tomatoes are covered with green branches. In this Gobi desert, which was once lamented as "the barren land in the middle of Gansu is the best in the world", the surface pipeline system and emitters drip water evenly and slowly into the soil at the root of crops. The application and popularization of new agricultural irrigation technology has greatly improved the efficiency of agricultural water use. By the end of 2017, the country had added more than 100 million mu of high-efficiency water-saving irrigation area. In the past five years, the effective utilization rate of farmland irrigation water has saved 20% to 50% compared with traditional irrigation.

　　In the industrial field, the state continues to promote water-saving processes, technologies and equipment, focusing on the implementation of water-saving technological transformation in high-water-consuming industries. In the service industry, we will implement water-saving technological transformation of high-water consumption service industries and strictly control high-water consumption service industries such as bathing and car washing. At the same time, strengthen the transformation of urban public water supply pipe network, comprehensively carry out the construction of water-saving units and residential quarters, and create an atmosphere of saving water for all.

　　■ Institutional innovation manages the long term.

　　"Look at the new river now, with clear water and fish shuttling. Wait another year, and at the junction of the three rivers, a new Weisha Wetland Park covering an area of 5,000 mu will be built soon. " On March 20th, Shu Quanhai, deputy director of Diaotai Sub-district Office in Fengxi New Town, Xixian New Area, Shaanxi Province, stood at the intersection of the new river and the Weihe River to inspect the river. He comes to this place two or three times a week.

　　Shu Quanhai said that since the implementation of the river length system, the effect of river management in the jurisdiction has been very obvious. At present, there is basically no surface garbage in the river.

　　It is reported that at present, 25 provinces in China have established the river length system, and the remaining provinces and Xinjiang Production and Construction Corps will be fully established by the end of June this year, and more than 320,000 river lengths at the provincial, city, county and township levels have been identified. There are 2865 lakes with a water area of more than 1 square kilometer in China. At present, 2180 lakes have established the lake length system, and it is planned to fully establish the system before the end of this year.

　　"Implementing the responsibility system for the heads of rivers and lakes is not a short-term expedient measure, but an institutional innovation with far-reaching significance in the water management system." Jia Shaofeng, a researcher at the Institute of Geographical Sciences and Resources, Chinese Academy of Sciences, said.

　　Innovative systems such as river length system and lake length system provide a guarantee for long-term and effective water resources protection and management. By introducing the river length system in many areas, the water quality has been obviously improved, and the appearance of rivers has been greatly improved. The beautiful picture of smooth rivers, clear water and green shores is becoming a reality. (Li Wei Lu Anqi Shi Hongqiang)

　　Nanning, China News Service, July 22 nd Title: The Growth of ASEAN Fruits in China: From "Luxury Goods" to "Explosive Prices"

　　Author Zhong Jianshan Huang Cong

　　In the hot midsummer night, in the night market food street in Pingxiang, a border town between China and Vietnam, a small shop named "Hu Xishi Fruit Fishing" is the most lively scene. Diners from all over China queue up to buy a bowl of authentic Southeast Asian fruit fishing.

　　The clerk quickly diced fresh tropical fruits and put them in a transparent glass bowl, covered with corn kernels, red beans and shredded coconut, poured two spoonfuls of thick and fragrant condensed milk, and a bowl of refreshing and sweet fruit fishing can be served.

　　"Fruit fishing is a hot item in Pingxiang. The fruit is fresh and varied, and it tastes delicious and fragrant." Luo Zi, a frequent visitor to Hu Xishi’s fruit fishing shop, said that a bowl of fruit fishing brought together fruits from many countries in Southeast Asia was only sold in 10 yuan RMB, which was "too cost-effective".

　　Pingxiang is the most convenient land route from China to Viet Nam and even ASEAN countries, and has maintained the status of "China’s largest fruit import and export city" for five consecutive years. Every year, more than 1 million tons of fruits are imported and exported from Pingxiang Friendship Pass and Puzhai Port, with more than 500,000 tons of imported fruits. Every 500 grams of ASEAN fruits entering China are imported through Pingxiang.

　　"In the past, the cost of importing fruits from Southeast Asia to China was high, the cold chain logistics network was not perfect, and the border clearance time was long, which led to the high price of fruits in Southeast Asia in China." Chen Renqi, general manager of Guangxi Hongguihua Import and Export Trading Co., Ltd., said in an interview with a reporter from China News Service that his company has been engaged in the import trade of Vietnamese dragon fruit for 22 years, during which he witnessed the change of fruits in Southeast Asia from "luxury goods" to "explosive prices".

　　Chen Renqi said that because the pitaya with white fruit pulp has the advantage of low sugar, the early import of pitaya from Vietnam was mainly aimed at domestic diabetic patients and high-end consumers. With China — With the establishment of ASEAN Free Trade Area, China and ASEAN countries have strengthened cooperation in customs clearance and transportation interconnection, and a large number of fruits from Southeast Asia, such as pitaya, began to enter China. As the import cost is gradually decreasing, the sales price of pitaya in China is increasingly "close to the people", and it has entered the family recipes of ordinary people.

　　"In the past, Vietnamese dragon fruit had to enter China Port, and it took one day to go through various customs clearance procedures such as inspection and quarantine, and it took two or three days to go through, which was very costly. Now the customs clearance time has been reduced to one hour, which is too convenient. " Chen Renqi said that there is a great demand for fruits from Southeast Asia in the China market. Apart from traditional sales channels such as farmers’ markets and supermarkets, emerging industries such as chain juice shops, theme restaurants and fruit experience halls with tropical fruits from ASEAN as their main products have also developed rapidly, enriching the dietary choices of China consumers.

　　In Pingxiang City, new dishes of Chinese food mixed with ASEAN fruits such as stewed pork ribs with peaches, steamed pear, stewed chicken soup with grapes and fried beef with dragon fruit have become the "new favorites" of local people in recent years. Recently, the fruit specialty restaurant and fruit experience center in China Pingxiang, the first fruit city in ASEAN, officially opened its doors for guests. The local official plans to deeply integrate the fruit trade industry with the tourism industry, and make the one-stop shopping and special fruit meals of ASEAN special fruits a new highlight on the tourist route of Friendship Pass.

　　In order to meet the domestic market demand, Chen Renqi’s company has set up several directly affiliated factories and several agent factories in Vietnam. Among them, the factory directly under Panche City, Vietnam is the largest, which can produce 15 containers of pitaya every day. Every year, the company imports pitaya from Vietnam with a total value of 1.5 billion yuan, and fresh fruit is in short supply in China.

　　"We are exploring more kinds of fruit products and sales channels in Southeast Asia." Chen Renqi said that in addition to pitaya, Vietnamese red meat jackfruit has been welcomed by consumers in China in recent years, and the company has also started import business. In Cambodia, the price of local mango fresh fruit has a great advantage over that of China. The company invested 40 million yuan to set up a dried mango processing factory in Cambodia. The dried mango products were transported through Sihanoukville Port, passed through Ho Chi Minh Port in Vietnam to Qinzhou Port in China, and then distributed to all parts of China. At present, the annual output value of dried mangoes exceeds 50 million yuan.

　　Chen Renqi said that more and more China enterprises are joining the fruit industry in ASEAN, which means that the amount of ASEAN fruits entering the China market will continue to expand in the future. In the increasingly perfect environment of international agricultural cooperation and market competition, ASEAN fruit in China "will not increase its quantity, but its quality will be continuously optimized". (End)

Today’s People’s Daily published an article "Adding More Seaside Space for Citizens and Tourists" in the column "Practice of Ludao Butterfly in Xiamen", paying attention to the continuous beach protection and restoration in Xiamen, Fujian.

The article said that in the 1980s, due to natural and human factors, the beaches in Xiamen were damaged to varying degrees. The common method of early coastal protection is to build hard revetment with riprap and reinforced concrete. Xiamen, on the other hand, follows the principle of "beach is suitable" to restore beaches, enhance coastal protection capacity and carry out systematic protection and restoration of beaches.

Since 2007, Xiamen has successively completed the protection and restoration of many beaches such as Guanyin Mountain, Convention and Exhibition Center and Gulangyu Island, with a cumulative restoration area of 1.65 million square meters. In the process of protection and restoration, Xiamen insists on leaving the most beautiful coastline to the people. The total beach area of the city is 2.4 million square meters, which adds more sea-friendly space for citizens and tourists. Xiamen organically combines sports, culture, tourism and leisure facilities, and organizes beach football matches, beach culture festivals and other activities. The once dirty beach has become a scenic beach and an activity area for cultural and sports events.

In recent years, Xiamen has continuously strengthened cooperation with scientific research institutes in beach protection and restoration, increased investment in scientific research and development, and carried out basic and applied scientific research on beach conservation. Together with the Third Institute of Oceanography of the Ministry of Natural Resources and other units, a number of industry standards have been compiled and approved by the Ministry of Natural Resources, which has become an important support for scientific and standardized beach maintenance and restoration projects. Related technologies have been gradually extended to Guangdong, Hainan and other provinces, and have also been applied to coastal protection projects in countries such as Thailand and Sri Lanka where the Belt and Road Initiative is jointly built.

(Observer News) According to Kyodo News, the world baseball classic (WBC) final was held in Miami, Florida, USA on the 21st local time. Japan defeated the last champion, the United States, 3-2 to win the championship for the third time. The last time Japan won the championship was the second WBC in 2009.

Japan won the championship. Figure from Kyodo News

Recently, Yan Ning, a famous structural biologist, announced that he would resign from Princeton University and set up the Academy of Medical Sciences in Shenzhen. In response to the latest research that she will focus on when she returns to China, she said that the discovery of structural biology is of great significance to the pharmaceutical industry, including the research on the interaction between drugs and hormones, which has more implications for drug development and disease treatment.

Yan Ning said, for example, that through the method of structural biology, scientists saw for the first time that two commonly used drugs used protein as a "scaffold", which directly "side by side" affected the normal function of protein.

Technological change promotes the development of structural biology.

Protein, as the scaffold and main substance of human tissues and organs, plays an important role in human life activities. In the cell, a large number of protein elements form the molecular machines, which performs important molecular processes in the cell through the interaction of protein, including the cell’s response to the external environment and the internal environment, and also forms a signal transduction network system with the interaction of protein as a link.

Structure By studying the three-dimensional structure, dynamic process and biological function of biological macromolecules, biology can provide more details of protein interaction and real-time dynamic process, thus helping scientists to understand molecular mechanism and explore the pathogenesis of diseases related to macromolecular dysfunction.

The development of biology not only contributes to the discovery of drugs, but also affects the research fields of life sciences including biochemistry, cell biology, genetic development, neurobiology, microbiology and pathopharmacology.

The development of science and technology has been promoting the progress of structural biology. In 2017, the Nobel Prize in Chemistry was awarded to cryoelectron microscopy, which can greatly improve the efficiency of analyzing the atomic resolution three-dimensional structure of large protein complexes; Moreover, researchers can freeze biomolecules in motion and visualize their motion process.

This breakthrough has brought a perfect storm to the field of structural biology. In recent years, important breakthroughs have been made in the field of life sciences. The work of China scientists such as Cheng Yifan, Shi Yigong, Yang Maojun and Liu Zhengfeng has also benefited from this technology. They have analyzed the important complex structure of atomic resolution. In addition, the enzyme that produces the protein that leads to Alzheimer’s syndrome was analyzed by cryomicroscope.

In August, 2015, Shi Yigong’s research team published an article in Nature, reporting the three-dimensional electron microscope structure of human γ -secretase with a resolution of 3.4 angstrom, and studying the function of the pathogenic mutant of γ -secretase based on the structure analysis, which provided an important foundation for understanding the working mechanism of γ -secretase and the pathogenesis of Alzheimer’s disease.

In February, 2020, after the outbreak of COVID-19, the research team of West Lake University successfully analyzed the full-length structure of novel coronavirus receptor ACE2 for the first time by using cryo-electron microscopy, which helped the research and development of drugs in COVID-19.

What does AI predict protein folding change?

With the help of artificial intelligence technology, DeepMind, a subsidiary of Google, recently announced 220 million kinds of protein structures predicted by AlphaFold software, which shocked the field of structural biology, because it indicates that artificial intelligence enterprises have begun to "truly hand over the power of Al to scientists all over the world".

Scientists compare the significance of this disruptive breakthrough with the human genome project. In the 1990s, when the Human Genome Project began to take shape, scientists realized that it was not enough to master the base arrangement of genes, but also to know the protein, the product of genes.

Shi Yigong, academician of China Academy of Sciences, structural biologist and president of West Lake University, commented on AlphaFold’s work: "Its accurate prediction of protein structure is the greatest contribution of artificial intelligence to the scientific field, and it is also one of the most important scientific breakthroughs made by mankind in the 21st century."

Shi Yigong once told China Business News: "AlphaFold represents the world’s leading artificial intelligence protein organization prediction system." At the same time, he said, China’s high-tech enterprises are catching up, expecting to bring surprises to the world in the near future.

He also said that the improvement of the accuracy of protein structure prediction will greatly benefit the pharmaceutical industry. "Artificial intelligence prediction of protein structure provides an important foundation for drug design and optimization. The structure of drug target proteins combined with all small molecule drugs can almost be wiped out by AlphaFold. " Shi Yigong said.

In the opinion of some scientists, although AlphaFold’s work is shocking, the accuracy of drug research and development prediction is not enough. Professor Liu Zhijie, executive director of iHuman Institute, Shanghai University of Science and Technology, told the First Financial Reporter: "It has been a long time to predict the protein structure. Now the accuracy of the prediction is definitely getting higher and higher, but it still hasn’t reached the precision of crystal structure."

Liu Zhijie First Financial News told the reporter that the crystal structure is the most accurate, and now artificial intelligence can predict the protein folding with the accuracy of electron microscope and nuclear magnetic resonance. In addition, because there are thousands of structures in protein, the difficulty of analysis is different. "If some protein sequences are similar to the known structure of artificial intelligence, it is easier to predict." Liu Zhijie said.

However, he still believes that with the continuous improvement of the prediction accuracy of protein folding, it will play a more important role in the field of life sciences in the future. "If the current prediction can reach the accuracy of electron microscope, some drugs can already be designed. Drug design is the biggest application field of artificial intelligence protein folding prediction." Said to Liu Zhijie First Financial Reporter.

Others think that with the development of artificial intelligence, there may not be so many structural biologists in the future. "Many researchers who do structural biology are actually more like technical service personnel. The more people there are, the more structures that can be analyzed. Therefore, in essence, a large part of their work depends on manpower. Now with AI, it is true that a large number of people who do structural biology have changed careers." A virus researcher told the First Financial News reporter.

However, for top structural biologists such as Shi Yigong, technology is only a powerful support for the "top brain", which can help them realize more ideas. "Every conscientious biologist should know how to make good use of the structural prediction of artificial intelligence." Shi Yigong said.

Professor Michael Levitt, winner of the Nobel Prize in Chemistry in 2013, told China Business News: "I think many structural biologists are not only doing structural research, but also doing a lot of work on protein function and drug research and development, just like Professor Yan Ning. Artificial intelligence only liberates a part of traditional manpower, but the progress of science still needs to rely on the smartest human brain. I’m afraid that artificial intelligence alone will not work. "

In recent years, a number of AI pharmaceutical companies have also been born in China. In this regard, Ewing Nan, academician of Chinese Academy of Sciences and president of Beijing Institute of Scientific Intelligence, pointed out to the First Financial Reporter: "The emergence of AI for Science research paradigm is an important historical opportunity for scientific and technological innovation, which not only expands the capability boundary of data-driven and physical model-driven models, but also is expected to promote the organic combination of the two, provide theoretical basis for further solving practical problems, and greatly narrow the distance between scientific research and practical application."

#270,000 elderly golden cases open##

The truth of this fact is that from 2009 to 2015, the old lady of Shanghai, Qian Mou, would abandon the husband who lost his ability to take care of his self -care in the hospital after paying some medical expenses during the hospitalization treatment, until the husband died alone. After the death of her husband, Qian still refused to go through the relevant procedures, and at the same time, he took the husband’s pension and accounted for himself.

On June 9, 2021, a case of fraud and abandonment of Qian, a public prosecution of the People’s Procuratorate of Minhang District, Shanghai, was held in the Minhang District People’s Court.

The truth of the case is very clear.

Some people think that pensions are in the country, and the national Tang monk meat, all Chinese citizens can eat, all of which are desirable. Therefore, it is not believed that the old lady of Shanghai Qian Mou is a criminal act. This view is particularly popular in the small and fresh meat little beauties. Because the little fresh meat and the little beauty thinks that farmers are reasonable to eat white food, everyone can not pay a penny social security, and they can be sits to share the social security provers for decades.

However, the understanding of farmers is extreme errors.

In the basic composition of pensions, all pensions of social insurance forms should belong to the private property of citizens who pay social security, and they are not owned by the whole society. In the basic pension of the national welfare form, [also known as the pension subsidy], that is, the country’s money from the city taxpayer to the farmer, the other social benefits that belong to the country to the farmers to the elderly.

Compared with the former, although it is also called pension, it is actually very different in nature. That is to say, the essence of social maintenance money is the private property of citizens who pay social security. They use their labor income to take out a part of their salary every month to invest in their future pensions, like bank savings. But more advanced than banks, these social property from citizens is managed by the state and has absolute security and insurance stability. The basic pension [also known as the pension subsidy for white hair to the farmers], the source of funds is not the citizen of the social security, but from the city’s hundreds of millions of taxpayers. Do not bear the tax responsibilities and obligations that every citizen should have, and the one billion farmers have no longer contributed a penny to the national fiscal tax for seventeen years. Therefore, these money -sweats from urban taxpayers have been distributed to farmers through the hands of the country. The money does not have the nature of private property, but has a social welfare nature.

Understanding the above principles, I understand that the old lady of Shanghai, Qian Mou, led her died of more than 270,000 yuan. The violent object was the private property of all social security citizens.

Similarly, those who do not pay a penny for social security, and those who have to pay the social security persons for decades of social security people are divided by farmers, which are those who eat white food selfish little fresh meat and little beauty. In fact Criminal behavior, they are public robbery, because their violations are the private property of the whole society who has paid social security for decades. But it is terrible that some people have committed guilty and do not know sin. Zhen Zhen has words that he is the savior of the peasant. He has called for robbery and plundering under the banner of speaking for farmers. As criminals, they have gone far enough on the road of illegal.

These pension articles videos are full of headlines. This fully shows that a large number of cyber criminals are active on the media network. They attempted to learn ancient bandits and live on the wealth of others by robbing others.

The opening of the old lady in Shanghai should let the small and fresh meat and little beauties who advocated robbery to calm the rational and rational girls. Please do not go further and further on the road of crime.